"Cafe de Pio" "Cafe de Pio" is located at #15 Artemio Fule St. San Pablo City Laguna,. The Cafe de Pio open until 9:00 pm. Me and my friend went here in Cafe de Pio, after the wedding of our friend. Our ordered nachos & over iced coffee, while eating we're playing a game and we enjoyed our food for almost Php 250.00 only.